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Macrolide Antibiotics - Erythromycin & Tylosin

 

Erythromycin was isolated from a soil fungus in 1952 by McGuire and colleagues and was found to be effective against Gram-positive bacteria. 

Erythromycin's mode of action differs from the beta-lactam antibiotics in that the antibiotic inhibit protein synthesis.  Derivatives of Erythromycin are particularly useful in treating respiratory infections.  These include Clarithromycin and azithromycin.  Most of the current recovery processes rely on solvent extraction although it is thought that the use of a more selective recovery process based on polymeric media could be of interest.

A non-solvent extraction process has been proposed for a closely related antibiotic - Tylosin - which is primarily used in animal health.

 

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