Decolorization

 

Within the pharmaceutical and biopharmaceutical industry, many process streams require purification. Typically, this requires that a specific impurity is removed or that a range of impurities are eliminated. In the latter case, these impurities are never fully characterized and are generally given the name “color species”. In all cases, the “color” is regarded as an impurity which must be removed in order to avoid any adverse quality problems downstream with the final pharmaceutical product. The removal of upstream color also serves to improve resin lifetime of expensive chromatography media that is used in downstream purification.

Traditionally, activated carbon has been used as a bulk decolorizing agent – although its use and disposal can be problematical, particularly if the regeneration is off-site. Ion exchange resins can provide a very cost effective solution for a variety of processes in order to minimize (or in some cases completely replace) the amount of carbon required.

 

SELECTED AMBERLITE ™ RESINS FOR DECOLORIZATION

 

Decolorization in aqueous process streams

Amberlite™ FPA40 Cl, Amberlite™ FPA53,
Amberlite™ FPA90 Cl, Amberlite™ FPA98 Cl
Amberlite™ FPX66, Amberlite™ XAD™7HP

 

Decolorization in solvent streams

 

Amberlite™ FPA53, Amberlite™ FPA98 Cl,
Amberlite™ FPC22, Amberlite™ FPA51
Amberlite™ XAD™7HP