Ion Exchange Resins - Healthcare
Deliquescent Drugs
Some API's are extremely sensitive to moisture in the environment to such an extent that if left in contact with moist air for even short periods of time, crystalline materials turn into problematical paste or even liquids. A good example of this type of deliquescent material is Sodium Valproate. Typically, the Pharmaceutical industry has sought to control this effect by using very tight environmental controls in their manufacturing and formulation areas.
Based on some recent work, there may now be an alternative approach using the unique properties of functional polymers to tackle this problem without resorting to expensive environmental measures.
Loading an API onto a functional polymer imparts some of the characteristics of the polymer onto the resulting resinate, in particular, the physical properties of a fine free flowing powder. It has been shown that the amount of moisture uptake by the API is significantly reduced and even at elevated moisture uptakes, the resinate remains a free flowing powder which is easily formulated.
Products Guidelines:
Drugs with cationic functionality (e.g. -COOH or Na / K salts)
Drugs with anionic functionality (-NH2, HCl salts etc.)
For further information, please contact Mr Marlin K. Kinzey
