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AMBERLITE™ XAD™ Adsorbent Resins for Capture, Desalting and Decolorization

Polymeric adsorbents are highly porous structures whose internal surfaces can adsorb and then desorb a wide variety of different species depending on the environment in which they are used. For example, in polar solvents such as water, polymeric adsorbents exhibit non-polar or hydrophobic behaviour and so can adsorb organic species that are sparingly soluble. This hydrophobicity is most pronounced with the styrenic adsorbents. In non-polar solvents, such as hydrocarbons, etc. most adsorbents exhibit slightly polar or hydrophilic properties and so will adsorb species with some degree of polarity. This polarity is most pronounced with the acrylic adsorbents and the phenolic adsorbents.

Purification strategies are developed to utilize these performance characteristics. In capture/concentration mode, Amberlite™ XAD™ media provide an excellent first purification step in the recovery of antibiotics such as Ceph C from complex fermentation broths. In the same application XAD™ resins perform decolorization and desalting functions as well.

 

AMBERLITE™
Chemistry

Surface area (m2/g)

Av. Pore diameter (Å)

Mean diameter (µ)

UCD90/D40
Applications
pStyDVB*
750
100
640
1.6
 Removal of solvents and low MW species
pStyDVB*
800
150
700
1.6
 Small molecules, antibiotic recovery
pStyDVB*
800
150
425
1.7
 Recovery and purification of antibiotics, natural products, amino acids and proteins
pStyDVB*
500
400
530
1.6
 Plant extracts, large MW product recovery
pStyDVB*
800
150
400
1.2
 Antibiotic recovery, chromatography
Aliphatic ester
500
450
560
1.7
 Plant extract, enzyme purification, peptides
Formophenolic
200
600
700
1.5
 Plant extracts, enzyme purification, peptides


*pStyDVB = Polystyrene DVB

 

Additional Information:

* AMBERLITE™ XAD™ Polymeric Adsorbent brochure (PDF file: 1800 kb)

* A New Cost Effective Adsorbent for the Capture and Purification of Antibiotics

 

Poster Session PREP 2008

Abstract: The purification of antibiotics such as Cephalosporin C from complex fermentation broths can be accomplished effectively using chromatographic adsorbents. A new chromatographic adsorbent, AMBERLITE™ XAD™18, has recently been introduced for the purification of antibiotics. AMBERLITE™ XAD™18 is a highly cross linked, polystyrenic adsorbent that has high capacity and excellent selectivity. Additionally the particle size distribution of this new adsorbent allows the use of either fixed bed column mode or simulated moving bed (SMB) operation. This work will demonstrate the utility of AMBERLITE™ XAD™18 for the purification of antibiotics. Read more (pdf file: 99 kb).

* Selecting the Right Adsorbent

* AMBERLITE™ XAD™ References